Nature Communications (Mar 2021)
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
- Lisa Suwandhi,
- Irem Altun,
- Ruth Karlina,
- Viktorian Miok,
- Tobias Wiedemann,
- David Fischer,
- Thomas Walzthoeni,
- Christina Lindner,
- Anika Böttcher,
- Silke S. Heinzmann,
- Andreas Israel,
- Ahmed Elagamy Mohamed Mahmoud Khalil,
- Alexander Braun,
- Ines Pramme-Steinwachs,
- Ingo Burtscher,
- Philippe Schmitt-Kopplin,
- Matthias Heinig,
- Martin Elsner,
- Heiko Lickert,
- Fabian J. Theis,
- Siegfried Ussar
Affiliations
- Lisa Suwandhi
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Irem Altun
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Ruth Karlina
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Viktorian Miok
- German Center for Diabetes Research (DZD)
- Tobias Wiedemann
- German Center for Diabetes Research (DZD)
- David Fischer
- Institute for Computational Biology, Helmholtz Center Munich
- Thomas Walzthoeni
- Institute for Computational Biology, Helmholtz Center Munich
- Christina Lindner
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Anika Böttcher
- German Center for Diabetes Research (DZD)
- Silke S. Heinzmann
- German Center for Diabetes Research (DZD)
- Andreas Israel
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Ahmed Elagamy Mohamed Mahmoud Khalil
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Alexander Braun
- Analytical Chemistry and Water Chemistry, Technical University of Munich
- Ines Pramme-Steinwachs
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Ingo Burtscher
- German Center for Diabetes Research (DZD)
- Philippe Schmitt-Kopplin
- German Center for Diabetes Research (DZD)
- Matthias Heinig
- Institute for Computational Biology, Helmholtz Center Munich
- Martin Elsner
- Analytical Chemistry and Water Chemistry, Technical University of Munich
- Heiko Lickert
- German Center for Diabetes Research (DZD)
- Fabian J. Theis
- Institute for Computational Biology, Helmholtz Center Munich
- Siegfried Ussar
- RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center Munich
- DOI
- https://doi.org/10.1038/s41467-021-21826-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocyte population that is enriched in adolescent subcutaneous fat and demonstrate that loss of Asc-1 triggers spontaneous beige adipocyte differentiation.
