Kidney & Blood Pressure Research (Mar 2015)

Indoxyl Sulfate, Not P-Cresyl Sulfate, is Associated with Advanced Glycation end Products in Patients on Long-Term Hemodialysis

  • Cheng-Jui Lin,
  • Jackson Lin,
  • Chi-Feng Pan,
  • Chih-Kuang Chuang,
  • Hsuan-Liang Liu,
  • Fang-Ju Sun,
  • Tuan-Jen Wang,
  • Han-Hsiang Chen,
  • Chih-Jen Wu

DOI
https://doi.org/10.1159/000368488
Journal volume & issue
Vol. 40, no. 2
pp. 121 – 129

Abstract

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Background/Aims: Advanced glycation end products (AGEs) are pro-inflammatory and pro-oxidative compounds that play a critical role in endothelial dysfunction and atherosclerosis. Protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), inhibit endothelial function. We explored the association of IS and PCS with AGEs in a hemodialysis (HD) cohort. Methods: This study was a cross-sectional study that recruited 129 stable patients on maintenance HD in a single medical center from July 1 to July 15, 2011. Serum levels of total and free IS, PCS and AGEs were measured concurrently. General laboratory results and patient background were also investigated. Results: Serum levels of AGEs were associated with total IS (r = 2.7, p Conclusions: These findings suggest that serum levels of total IS were associated with AGEs levels, which may participate in the process of atherosclerosis.

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