MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

Can Liu; Ruifang Liu; Dingxiao Zhang; Qu Deng; Bigang Liu; Hsueh-Ping Chao; Kiera Rycaj; Yoko Takata; Kevin Lin; Yue Lu; Yi Zhong; John Krolewski; Jianjun Shen; Dean G. Tang

doi:10.1038/ncomms14270

Nature Communications (Jan 2017)

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

Can Liu,
Ruifang Liu,
Dingxiao Zhang,
Qu Deng,
Bigang Liu,
Hsueh-Ping Chao,
Kiera Rycaj,
Yoko Takata,
Kevin Lin,
Yue Lu,
Yi Zhong,
John Krolewski,
Jianjun Shen,
Dean G. Tang

Affiliations

Can Liu: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Ruifang Liu: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Dingxiao Zhang: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Qu Deng: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Bigang Liu: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Hsueh-Ping Chao: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Kiera Rycaj: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Yoko Takata: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Kevin Lin: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Yue Lu: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Yi Zhong: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
John Krolewski: Department of Cancer Genetics, Roswell Park Cancer Institute
Jianjun Shen: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Dean G. Tang: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms14270
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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