Synthetic and Systems Biotechnology (Dec 2024)

Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products

  • Kemeng Li,
  • Zhengyan Guo,
  • Liping Bai

DOI
https://doi.org/10.1016/j.synbio.2024.05.012
Journal volume & issue
Vol. 9, no. 4
pp. 701 – 712

Abstract

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Digitoxose, a significant 2,6-dideoxyhexose found in nature, exists in many small-molecule natural products. These digitoxose-containing natural products can be divided into steroids, macrolides, macrolactams, anthracyclines, quinones, enediynes, acyclic polyene, indoles and oligosaccharides, that exhibit antibacterial, anti-viral, antiarrhythmic, and antitumor activities respectively. As most of digitoxose-containing natural products for clinical application or preclinical tests, this review also summarizes the biosynthesis of digitoxose, and application of compound diversification by introducing sugar plasmids. It may provide a practical approach to expanding the diversity of digitoxose-containing products.

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