Intramolecular Barbier reaction in water: Cyclopentane and cyclohexane ring closure

Abstract

Zinc or indium promoted intramolecular Barbier reactions of aldehydes containing a suitably positioned allylic or propargylic halide unit afford unsaturated cyclic alcohols in moderate yields.

Keywords

• barbier reactions
• cyclisation
• allylation
• allenes
• zinc
• indium.