Evaluation of eltrombopag in patients with aplastic anemia in real-world experience

Akiko Konishi; Aya Nakaya; Shinya Fujita; Atsushi Satake; Takahisa Nakanishi; Yoshiko Azuma; Yukie Tsubokura; Ryo Saito; Masaaki Hotta; Hideaki Yoshimura; Kazuyoshi Ishii; Tomoki Ito; Shosaku Nomura

Leukemia Research Reports (Jan 2019)

Evaluation of eltrombopag in patients with aplastic anemia in real-world experience

Akiko Konishi,
Aya Nakaya,
Shinya Fujita,
Atsushi Satake,
Takahisa Nakanishi,
Yoshiko Azuma,
Yukie Tsubokura,
Ryo Saito,
Masaaki Hotta,
Hideaki Yoshimura,
Kazuyoshi Ishii,
Tomoki Ito,
Shosaku Nomura

Affiliations

Akiko Konishi: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Aya Nakaya: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan; Corresponding author at: First Department of Internal Medicine, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, Osaka 573-1010, Japan.
Shinya Fujita: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Atsushi Satake: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Takahisa Nakanishi: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Yoshiko Azuma: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Yukie Tsubokura: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Ryo Saito: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Masaaki Hotta: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Hideaki Yoshimura: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Kazuyoshi Ishii: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Tomoki Ito: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan
Shosaku Nomura: First Department of Internal Medicine, Kansai Medical University, Japan; Departments of Pathology and Laboratory Medicine, Kansai Medical University, Japan

Journal volume & issue: Vol. 11
pp. 11 – 13

Abstract

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Background: Although eltrombopag has recently been approved for treating AA, the effects of its clinical use remain unknown. Methods: We retrospectively analyzed 11 patients with AA, who had been treated with eltrombopag from August 2017 to May 2018. Results: Overall response rate was 55%. There was tri-lineage recovery in four patients and platelet recovery in two. The reactive time was within 8 weeks after treatment initiation. Stage at the initial assessment, the neutrophil-to-lymphocyte ratio and platelet counts were significantly different between the responders and non-responders. Conclusion: Eltrombopag is a promising agent for treating patients with any degree of AA. Keywords: Eltrombopag, Aplastic anemia, Neutrophil-to-lymphocyte ratio, Real-world setting

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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