The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42

Sui-Chih Tien; Hsiao-Hui Lee; Ya-Chi Yang; Miao-Hsia Lin; Yu-Ju Chen; Zee-Fen Chang

doi:10.1038/ncomms10420

Nature Communications (Jan 2016)

The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42

Sui-Chih Tien,
Hsiao-Hui Lee,
Ya-Chi Yang,
Miao-Hsia Lin,
Yu-Ju Chen,
Zee-Fen Chang

Affiliations

Sui-Chih Tien: Institute of Biochemistry and Molecular Biology, National Yang-Ming University
Hsiao-Hui Lee: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University
Ya-Chi Yang: Institute of Biochemistry and Molecular Biology, National Yang-Ming University
Miao-Hsia Lin: Institute of Chemistry, Academia Sinica
Yu-Ju Chen: Institute of Chemistry, Academia Sinica
Zee-Fen Chang: Institute of Biochemistry and Molecular Biology, National Yang-Ming University

DOI: https://doi.org/10.1038/ncomms10420
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Cdc42 activity is important for apical-basal epithelial polarity. Here, the authors show that Shp2 disrupts Cdc42 activation, and by reducing the expression of histone deactylase 6, restores epithelial lumen formation in a cdc42-independent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal