Otorhinolaryngology Department, Institute of Sport Medicine, Sport e Salute, Rome, Italy
Francesco Cappello
Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, and Euro-Mediterranean Institute of Science and Technology, Palermo, Italy
Roberto Fiore
Sport Medicine Department, Institute of Sport Medicine, Sport e Salute, Rome, Italy
Giuseppe Bastone
Sport Medicine Department, Institute of Sport Medicine, Sport e Salute, Rome, Italy
Gianfranco Gualdi
Radiology Department, Casa di Cura Pio XI and Sapienza University, Rome, Italy
Saadi Sollaku
Nuclear Medicine, Casa di Cura Pio XI, Rome, Italy
Emanuele Casciani
Nuclear Medicine, Casa di Cura Pio XI, Rome, Italy
Federica Tortorella
Otorhinolaryngology Department, Institute of Sport Medicine, Sport e Salute, Rome, Italy
Pasquale Longo
Otorhinolaryngology Department, Institute of Sport Medicine, Sport e Salute, Rome, Italy
Eleonora Centanini
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy
Silva Pavaci
Otorhinolaryngology Department, Institute of Sport Medicine, Sport e Salute, Rome, Italy
Federica Sangiuolo
Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy
Maria Patrizia Patrizi
Fondazione Livio Patrizi, Rome, Italy
Shane Miersch
Department of Molecular Genetics, The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
Sachdev S. Sidhu
Department of Molecular Genetics, The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
Virgilio Sacchini
Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA
Giuseppe Novelli
Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy; IRCCS Neuromed Institute, Pozzilli, Italy; Department of Pharmacology, School of Medicine, University of Nevada, Reno, NV, USA; Corresponding author. Department of Biomedicine and Prevention, Tor Vergata University of Rome, Via Montpellier 1, 00173 Rome, Italy.
The currently available nebulization devices have a slow aerosol flow and produce vapor with large microdrops. Improved devices that achieve higher airflow and produce smaller microdrops are needed to improve the clinical care of patients. To address this critical need, we developed a novel system for the molecular vaporization of liquids. This device vaporizes an active pharmacological substance dissolved in water, alcohol, or a mixture of water and alcohol using two energy sources at the same time: high-frequency ultrasound and thermal induction. Application of energy to a solution contained in the device’s tank allows, within tens of seconds, for the vaporization of the solution itself, with the generation of a vapor consisting of microdrops of very small diameter (0.2–0.3 μm). In this article, we illustrate the technology used, the main verification tests performed, and the primary fields of application for this device. In particular, the advantages of both the aerosol delivery system and the administration system are highlighted.
