Nature Communications (Jan 2022)

The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity

  • Sarah M. Morgan,
  • Hideki Tanizawa,
  • Lisa Beatrice Caruso,
  • Michael Hulse,
  • Andrew Kossenkov,
  • Jozef Madzo,
  • Kelsey Keith,
  • Yinfei Tan,
  • Sarah Boyle,
  • Paul M. Lieberman,
  • Italo Tempera

DOI
https://doi.org/10.1038/s41467-021-27894-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Genome folding in the nucleus plays an important role in regulating gene expression. Here the authors show that 3D genome architecture also plays an important role for gene expression adaptability for the Epstein-Barr Virus (EBV), a virus that is associated with cancer. They also observe major changes in the fold of the EBV chromosome between silent and transcriptional active viral genomes.