α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling

Mingzhu Huang; Mingzhu Huang; Bianbian Wang; Bianbian Wang; Xiaopeng Li; Xiaopeng Li; Chongluo Fu; Changhe Wang; Xinjiang Kang; Xinjiang Kang

doi:10.3389/fnins.2019.00028

Frontiers in Neuroscience (Jan 2019)

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling

Mingzhu Huang,
Mingzhu Huang,
Bianbian Wang,
Bianbian Wang,
Xiaopeng Li,
Xiaopeng Li,
Chongluo Fu,
Changhe Wang,
Xinjiang Kang,
Xinjiang Kang

Affiliations

Mingzhu Huang: School of Life Sciences, Liaocheng University, Liaocheng, China
Mingzhu Huang: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, China
Bianbian Wang: School of Life Sciences, Liaocheng University, Liaocheng, China
Bianbian Wang: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, China
Xiaopeng Li: School of Life Sciences, Liaocheng University, Liaocheng, China
Xiaopeng Li: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, China
Chongluo Fu: School of Life Sciences, Liaocheng University, Liaocheng, China
Changhe Wang: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, China
Xinjiang Kang: School of Life Sciences, Liaocheng University, Liaocheng, China
Xinjiang Kang: Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China

DOI: https://doi.org/10.3389/fnins.2019.00028
Journal volume & issue: Vol. 13

Abstract

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α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of Parkinson’s disease. However, the physiological roles of α-Syn remain poorly understood. Recent studies have indicated a critical role of α-Syn in the sensing and generation of membrane curvature during vesicular exocytosis and endocytosis. It has been known to modulate the assembly of SNARE complex during exocytosis including vesicle docking, priming and fusion steps. Growing evidence suggests that α-Syn also plays critical roles in the endocytosis of synaptic vesicles. It also modulates the availability of releasable vesicles by promoting synaptic vesicles clustering. Here, we provide an overview of recent progresses in understanding the function of α-Syn in the regulation of exocytosis, endocytosis, and vesicle recycling under physiological and pathological conditions.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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