Nature Communications (Jun 2018)

In vivo base editing of post-mitotic sensory cells

  • Wei-Hsi Yeh,
  • Hao Chiang,
  • Holly A. Rees,
  • Albert S. B. Edge,
  • David R. Liu

DOI
https://doi.org/10.1038/s41467-018-04580-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Base editing allows the precise introduction of point mutations into cellular DNA without requiring double-stranded DNA breaks or homology-directed repair, which is inefficient in postmitotic cells. Here the authors demonstrate in vivo base editing of post-mitotic somatic cells in the postnatal mouse inner ear with physiological outcomes.