Frontiers in Microbiology (Oct 2021)
The Microbiome–Gut–Brain Axis, a Potential Therapeutic Target for Substance-Related Disorders
- Xuan Fu,
- Xuan Fu,
- Xuan Fu,
- Xuan Fu,
- Xuan Fu,
- Xuan Fu,
- Ti Chen,
- Jingda Cai,
- Jingda Cai,
- Jingda Cai,
- Jingda Cai,
- Jingda Cai,
- Jingda Cai,
- Bo Liu,
- Bo Liu,
- Bo Liu,
- Bo Liu,
- Bo Liu,
- Bo Liu,
- Yaohui Zeng,
- Yaohui Zeng,
- Yaohui Zeng,
- Yaohui Zeng,
- Yaohui Zeng,
- Yaohui Zeng,
- Xiaojie Zhang,
- Xiaojie Zhang,
- Xiaojie Zhang,
- Xiaojie Zhang,
- Xiaojie Zhang,
- Xiaojie Zhang
Affiliations
- Xuan Fu
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Xuan Fu
- National Clinical Research Center on Mental Disorders, Changsha, China
- Xuan Fu
- National Technology Institute on Mental Disorders, Changsha, China
- Xuan Fu
- Hunan Medical Center for Mental Health, Changsha, China
- Xuan Fu
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Xuan Fu
- Mental Health Institute of Central South University, Changsha, China
- Ti Chen
- Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, China
- Jingda Cai
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Jingda Cai
- National Clinical Research Center on Mental Disorders, Changsha, China
- Jingda Cai
- National Technology Institute on Mental Disorders, Changsha, China
- Jingda Cai
- Hunan Medical Center for Mental Health, Changsha, China
- Jingda Cai
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Jingda Cai
- Mental Health Institute of Central South University, Changsha, China
- Bo Liu
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Bo Liu
- National Clinical Research Center on Mental Disorders, Changsha, China
- Bo Liu
- National Technology Institute on Mental Disorders, Changsha, China
- Bo Liu
- Hunan Medical Center for Mental Health, Changsha, China
- Bo Liu
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Bo Liu
- Mental Health Institute of Central South University, Changsha, China
- Yaohui Zeng
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Yaohui Zeng
- National Clinical Research Center on Mental Disorders, Changsha, China
- Yaohui Zeng
- National Technology Institute on Mental Disorders, Changsha, China
- Yaohui Zeng
- Hunan Medical Center for Mental Health, Changsha, China
- Yaohui Zeng
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Yaohui Zeng
- Mental Health Institute of Central South University, Changsha, China
- Xiaojie Zhang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Xiaojie Zhang
- National Clinical Research Center on Mental Disorders, Changsha, China
- Xiaojie Zhang
- National Technology Institute on Mental Disorders, Changsha, China
- Xiaojie Zhang
- Hunan Medical Center for Mental Health, Changsha, China
- Xiaojie Zhang
- Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Xiaojie Zhang
- Mental Health Institute of Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fmicb.2021.738401
- Journal volume & issue
-
Vol. 12
Abstract
Substance addiction is a complex worldwide public health problem. It endangers both personal life and social stability, causing great loss on economy. Substance-related disorder is considered to be a complicated chronic brain disorder. It resulted from interactions among pharmacological properties of addictive substances, individual susceptibility, and social–environmental factors. Unfortunately, there is still no ideal treatment for this disorder. Recent lines of evidence suggest that gut microbiome may play an important role in the pathogenesis of neuropsychiatric disorders, including substance-related disorders. This review summarizes the research on the relationship between gut microbiome and substance-related disorders, including different types of substance, different individual susceptibility, and the occurrence and development of substance-induced mental disorders. We also discuss the potentiation of gut microbiome in the treatment of substance-related disorders, especially in the treatment of substance-induced mental disorders and manipulation on individuals’ responsiveness to addictive substances.
Keywords
- microbiome-gut-brain axis (MGBA)
- microbiota manipulation
- substance-related disorders
- gut microbiota
- fecal microbiome transplantation
