Hubungan antara Fatigue, Jumlah CD4, dan Kadar Hemoglobin pada Pasien yang Terinfeksi Human Immunodeficiency Virus (HIV)

Abstract

Keberadaan Human Immunodeficiency Virus (HIV) di dalam tubuh secara terus menerus menyebabkan gangguan pada hampir semua sistem tubuh yang berdampak pada munculnya gejala kelelahan (fatigue). Fatigue banyak dilaporkan pada penderita HIV/AIDS dengan prevalensi berkisar antara 20% sampai 60%. Penelitian ini bertujuan menguji hubungan antara fatigue dengan jumlah CD4 dan kadar Hb pada pasien HIV/AIDS. Sebanyak 77 responden direkrut secara purposif di sebuah Klinik Rawat Jalan Rumah Sakit di Kota Bandung. Fatigue diukur menggunakan kuesioner HIV Related Fatigue Score (HRFS). Data yang terkumpul dianalisis menggunakan uji pearson correlation. Hasil penelitian menunjukkan terdapat hubungan yang bermakna antara fatigue dengan jumlah CD4 dalam darah (r = -.289, p< 0.05) dan kadar Hb (r = -.349, p< 0.05). Selain itu, kadar Hb memiliki hubungan yang bermakna dengan jumlah CD4 pada pasien HIV/AIDS (r = .360, p < .01). Hasil penelitian ini mengindikasikan perlunya monitoring kadar CD4 dan Hb secara berkala dan melakukan intervensi untuk mengatasi penurunan Hb dan CD4 sesegera mungkin sehingga dapat mencegah agar fatigue tidak berkelanjutan. Kata kunci: CD4, fatigue, hemoglobin, HIV/AIDS. The Correlation of Between Fatigue, CD4 Cell Count, and Hemoglobin Level among HIV/AIDS Patients Abstract The existence of Human Immunodeficiency Virus (HIV) in the body continuously causes disruption in almost all body systems that impact on the emergence of symptoms of fatigue. Fatigue was widely reported in HIV/AIDS patients with prevalence ranging from 20% to 60%. This study examined the relationship between fatigue and CD4 cell count and hemoglobin levels in HIV/AIDS patients. A total of 77 respondents were recruited purposively in Outpatient Clinic, General Hospital Bandung City. Fatigue was measured using the HIV Related Fatigue Score (HRFS) questionnaire. The collected data were analyzed using pearson correlation product moment. The results showed there were significant relationship between fatigue and CD4 count in blood (r = -.289, p< 0.05) and hemoglobin level (r = -.349, p< 0.05). In addition, CD4 had significantly correlation with Hb (r = .360, p < .01). The results of this study indicated that nurses or health care providers need to periodically monitor the CD4 and Hb levels and provide early intervention to manage the hemoglobin and CD4 cell count at optimum levels to prevent prolonging fatiguel. Keywords: CD4, fatigue, hemoglobin, HIV/AIDS.