Nature Communications (Jun 2021)
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning
- Joana Esteves de Lima,
- Cédrine Blavet,
- Marie-Ange Bonnin,
- Estelle Hirsinger,
- Glenda Comai,
- Laurent Yvernogeau,
- Marie-Claire Delfini,
- Léa Bellenger,
- Sébastien Mella,
- Sonya Nassari,
- Catherine Robin,
- Ronen Schweitzer,
- Claire Fournier-Thibault,
- Thierry Jaffredo,
- Shahragim Tajbakhsh,
- Frédéric Relaix,
- Delphine Duprez
Affiliations
- Joana Esteves de Lima
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Cédrine Blavet
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Marie-Ange Bonnin
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Estelle Hirsinger
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Glenda Comai
- Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS UMR 3738
- Laurent Yvernogeau
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Marie-Claire Delfini
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Léa Bellenger
- Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-FR3631, ARTbio Bioinformatics Platform, Inserm US 037
- Sébastien Mella
- Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS UMR 3738
- Sonya Nassari
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Catherine Robin
- Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences (KNAW), Regenerative Medicine Center, University Medical Center Utrecht
- Ronen Schweitzer
- Research Division, Shriners Hospital for Children
- Claire Fournier-Thibault
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Thierry Jaffredo
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- Shahragim Tajbakhsh
- Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS UMR 3738
- Frédéric Relaix
- Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB
- Delphine Duprez
- Developmental Biology Laboratory, Institut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-UMR 7622
- DOI
- https://doi.org/10.1038/s41467-021-24157-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The dogma is that limb muscle cells originate from somite, while connective tissue fibroblasts derive from lateral plate mesoderm. Here the authors identify a fibroblast population that undergoes myoblast conversion in response to BMP and contributes nuclei to myotubes at the myotendinous junction.
