Mis-Genotyping of Some Hepatitis D Virus Genotype 2 and 5 Sequences Using HDVdb
Caroline Charre,
Frédéric le Gal,
Paul Dény,
Caroline Scholtès
Affiliations
Caroline Charre
University Claude Bernard Lyon 1 (UCBL1), University of Lyon, 69008 Lyon, France
Frédéric le Gal
Laboratoire de Microbiologie Clinique, Hôpitaux Universitaires de Paris Seine Saint-Denis, Site Avicenne, Université Sorbonne Paris Cité, 93022 Bobigny, France
Paul Dény
University Claude Bernard Lyon 1 (UCBL1), University of Lyon, 69008 Lyon, France
Caroline Scholtès
University Claude Bernard Lyon 1 (UCBL1), University of Lyon, 69008 Lyon, France
Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong genotyping results. The current HDVdb algorithm should be carefully considered as a “beta-version” and warrants algorithm core corrections, as soon as possible, for an optimal and beneficial use.
