Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report

Helen Ke, MBBS (Hons); Anthony J. Gill, AM, MBBS, FRCPA; Catriona McKenzie, MBBS (Hons1), FRCPA; James G. Kench, MBBS, Bsc(Med), FRCPA; Renee C.F. Chan, MBBS(Hons1), FRCPA; Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP; Michael Fulham, MBBS(Hons), FRACP; Cherry Koh, MBBS (Hons), MS, FRACS; Steven Kao, BHB, MBChB, PhD, FRACP

JTO Clinical and Research Reports (Nov 2021)

Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report

Helen Ke, MBBS (Hons),
Anthony J. Gill, AM, MBBS, FRCPA,
Catriona McKenzie, MBBS (Hons1), FRCPA,
James G. Kench, MBBS, Bsc(Med), FRCPA,
Renee C.F. Chan, MBBS(Hons1), FRCPA,
Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP,
Michael Fulham, MBBS(Hons), FRACP,
Cherry Koh, MBBS (Hons), MS, FRACS,
Steven Kao, BHB, MBChB, PhD, FRACP

Affiliations

Helen Ke, MBBS (Hons): University of Sydney, Sydney, Australia; Asbestos Diseases Research Institute, Concord, Australia
Anthony J. Gill, AM, MBBS, FRCPA: University of Sydney, Sydney, Australia; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia; NSW Health Pathology, Department of Anatomical Pathology Royal North Shore Hospital, St Leonards, Australia
Catriona McKenzie, MBBS (Hons1), FRCPA: University of Sydney, Sydney, Australia; NSW Health Pathology, Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia
James G. Kench, MBBS, Bsc(Med), FRCPA: University of Sydney, Sydney, Australia; NSW Health Pathology, Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia
Renee C.F. Chan, MBBS(Hons1), FRCPA: Electron Microscopy Unit, Department of Anatomical Pathology, Concord Hospital, Concord, Australia
Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP: University of Sydney, Sydney, Australia; Department of Medical Oncology, Royal North Shore Hospital, St Leonards, Australia
Michael Fulham, MBBS(Hons), FRACP: University of Sydney, Sydney, Australia; Department of Molecular Imaging, Royal Prince Alfred Hospital, Sydney, Australia
Cherry Koh, MBBS (Hons), MS, FRACS: Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, Australia; Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital, Sydney, Australia; Discipline of Surgery, Faculty of Medicine, and Health, University of Sydney, Sydney, Australia
Steven Kao, BHB, MBChB, PhD, FRACP: University of Sydney, Sydney, Australia; Asbestos Diseases Research Institute, Concord, Australia; Department of Medical Oncology, Chris O’Brien Lifehouse, Camperdown, Australia; Corresponding author. Address for correspondence: Steven Kao, BHB, MBChB, PhD, FRACP, Department of Medical Oncology, Chris O’Brien Lifehouse, Missenden Road Camperdown, NSW Australia 2050.

Journal volume & issue: Vol. 2, no. 11
p. 100236

Abstract

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Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have not been described. This case report describes the clinical course of a 19-year-old man diagnosed with malignant peritoneal mesothelioma with EWSR1-ATF1 fusion localized to the abdomen. His disease followed an aggressive course and resulted in limited survival (18 mo). There was treatment resistance to several lines of conventional local and systemic treatments for peritoneal mesothelioma and biologically targeted MET inhibition with crizotinib. More research is required in this rare subtype of peritoneal mesothelioma.

Published in JTO Clinical and Research Reports

ISSN: 2666-3643 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/jto-clinical-and-research-reports/

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