Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus <i>Chaetomium madrasense</i> 375
Qing-Feng Guo,
Zhen-Hua Yin,
Juan-Juan Zhang,
Wen-Yi Kang,
Xue-Wei Wang,
Gang Ding,
Lin Chen
Affiliations
Qing-Feng Guo
Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450063, Henan, China
Zhen-Hua Yin
Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450063, Henan, China
Juan-Juan Zhang
Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450063, Henan, China
Wen-Yi Kang
Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450063, Henan, China
Xue-Wei Wang
Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China
Gang Ding
Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Union Medical College, Beijing 100193, China
Lin Chen
Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450063, Henan, China
Two new cytochalasans, Chaetomadrasins A (1) and B (2), along with six known analogues (3−8), were isolated from the solid-state fermented culture of desert soil-derived Chaetomium madrasense 375. Their structures were clarified by comprehensive spectroscopic analyses, and the absolute configurations of Compounds 1 and 2 were confirmed by electronic circular dichroism (ECD) and calculated ECD. For the first time, Chaetomadrasins A (1), which belongs to the chaetoglobosin family, is characterized by the presence of all oxygen atoms in the form of Carbonyl. Chaetomadrasin B (2) represents the first example of chaetoglobosin type cytochalasan characterized by a hydroxy unit and carbonyl group fused to the indole ring. Compounds 1 and 2 displayed moderate cytotoxicity against HepG2 human hepatocellular carcinoma cells.
