Acrokeratosis verruciformis of Hopf in an immunosuppressed adult: an exclusive occurrence

Abstract

Acrokeratosis verruciformis of Hopf (AKV) is a rare autosomal dominant genodermatosis. It can be characterized by warty papules with a symmetrical distribution involving dorsae of hands and feet. It can also involve elbows, knees, nails, and palms. It is more frequently seen in childhood but can also occur in adults. Various treatment methods have been tried, but superficial ablation is known to be the treatment of choice. In this case, an adult male with breast carcinoma who was also hepatitis B and C reactive presented with flesh-colored papular eruptions over bilateral hands and feet. No familial association was another unusual finding in this case. It has to be differentiated from Darier’s disease. Histopathology helped to confirm the diagnosis of AKV. Moreover, the findings pointed toward the sporadic form of AKV in our patient. Rarity of data regarding the association of immunosuppression and AKV makes this an intriguing case.

Keywords

• acrokeratosis verruciformis
• immunosuppression
• nonfamilial