Glanzmann Thrombasthenia Associated with Siderotic Synovitis and Arthropathy: A Case Report

Abstract

Mouhammad J Alawad,1 Mohammad Abu-Tineh,2 Awni Alshurafa,2 Alaa Al-Taie,3 Anil Yousaf,2 Mohamed A Yassin2 1Department of Medical Education, Internal Medicine Residency Program, Hamad Medical Corporation, Doha, Qatar; 2Department of Medical Oncology, Hematology and BMT Section, National Center for Hamad Medical Corporation, Doha, Qatar; 3Clinical Imaging Department, Hamad Medical Corporation, Doha, QatarCorrespondence: Mouhammad J Alawad, Department of Medical Education, Internal Medicine Residency Program, Hamad Medical Corporation, PO Box 3050, Doha, Qatar, Tel [phone], Fax [phone], Email [email protected]: Glanzmann thrombasthenia is a bleeding disorder with a low incidence. It typically manifests as superficial bleeding episodes, which tend to be mild. Deep organ involvement is not uncommon but remains rare due to the rarity of the disease itself and the unusual association between platelet disorders and deep organ implications. A 17-year-old boy with Glanzmann thrombasthenia since infancy developed ankle pain after a minor trauma. His initial workup was negative, but he continued to experience ankle pain. A magnetic resonance imaging (MRI) done after four weeks suggested siderotic synovitis. The patient was lost to follow-up after that and returned after two years with recurrent left ankle pain. Imaging and studies have shown evidence of chronic arthropathy. A specialized orthopedic team assessed the patient. The patient underwent intra-articular steroid injection for pain relief and was referred to continue physical therapy. In conclusion, hemarthrosis is more common in hemophilia than in platelet disorders and has potential morbidity and quality-of-life implications.Keywords: Glanzmann thrombasthenia, hemarthrosis, synovitis

Keywords

• glanzmann thrombasthenia
• hemarthrosis
• synovitis