DEMOGRAPHICAL, VIRO-IMMUNOLOGICAL, CLINICAL AND THERAPEUTICAL CHARACTERISTICS OF HIV INFECTED PATIENTS IN A “EPIDEMIOLOGICALLY UNEXPLORED” REGION OF ITALY (CALABRIA REGION): THE CALABRHIV COHORT.
Mediterranean Journal of Hematology and Infectious Diseases. 2015;7(1):e2015054-e2015054 DOI 10.4084/mjhid.2015.054
Journal Title: Mediterranean Journal of Hematology and Infectious Diseases
ISSN: 2035-3006 (Online)
Publisher: PAGEPress Publications
LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Country of publisher: Italy
Language of fulltext: English
Full-text formats available: PDF, HTML
Maria Concetta Postorino (Infectious Diseases Unit, “Magna Graecia” University, Catanzaro)
Maria Stella Carpentieri
Abstract | Full Text
Background and Objectives HIV epidemics may differ among epidemiological contexts. We aimed at constructing an HIV clinical cohort whose main epidemiological, clinical and therapeutical characteristics are described (the CalabrHIV cohort, Calabria Region, Southern Italy). Methods The CalabrHIV cohort includes all HIV patients on active follow-up in all infectious disease centers in the Calabria Region as at October 2014. All information were recorded in a common electronic database. Not-infectious co-morbidities (such as cardiovascular diseases, bone fractures, diabetes, renal failure and hypertension) were also studied. Results 548 patients (68% males; 63% aged <50 years) were included in the CalabrHIV cohort. Major risk factors: sexual transmission (49%) and intravenous drug use (34%). 39% patients had HCV and/or HBV co-infection. An high percentage of late presenters was observed (68.4% patients with CD4+ nadir <350/mm3and 38.5% patients with AIDS at baseline). 83% patients on HAART had actually undetectable HIV-RNA. Hypertension was the most frequent co-morbidity (21.5%). Multi-morbidity was more frequent in >50 years-old patients than in <50 years-old ones (30% vs. 6%; p<0.0001). Co-morbidity was more frequent in HCV and/or HBV co-infected than in HIV mono-infected patients (46.6% vs. 31.7%: p=0.0006). Conclusion This cohort presentation study sheds light, for the first time, on HIV patients’ characteristics in the Calabria Region. Despite a small number of officially reported cases, the size of the cohort was substantial. We showed that HIV infected patients with chronic hepatites, were affected by concomitant not-infectious co-morbidities more than the HIV mono-infected individuals. New HCV treatments are eagerly awaited.