DEMOGRAPHICAL, VIRO-IMMUNOLOGICAL, CLINICAL AND THERAPEUTICAL CHARACTERISTICS OF HIV INFECTED PATIENTS IN A “EPIDEMIOLOGICALLY UNEXPLORED” REGION OF ITALY (CALABRIA REGION): THE CALABRHIV COHORT.

Mediterranean Journal of Hematology and Infectious Diseases. 2015;7(1):e2015054-e2015054 DOI 10.4084/mjhid.2015.054

 

Journal Homepage

Journal Title: Mediterranean Journal of Hematology and Infectious Diseases

ISSN: 2035-3006 (Online)

Publisher: PAGEPress Publications

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs

Country of publisher: Italy

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Maria Concetta Postorino (Infectious Diseases Unit, “Magna Graecia” University, Catanzaro)

Filippo Luciani

Carmelo Mangano

Maria Stella Carpentieri

Paolo Scerbo

Armando Priamo

Giuseppina Berardelli

Roberto Marino

Alfredo Vallone

Nicola Serrao

Vincenzo Pisani

Chiara Costa

Albano Terremoto

Giuseppe Foti

Lucio Cosco

Massimo Calderazzo

Domenico Corigliano

Preziosa Scordo

Carlo Torti

Alessio Strazzulla

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

Background and Objectives   HIV epidemics may differ among epidemiological contexts. We aimed at constructing an HIV clinical cohort whose main epidemiological, clinical and therapeutical characteristics are described (the CalabrHIV cohort, Calabria Region, Southern Italy).   Methods   The CalabrHIV cohort includes all HIV patients on active follow-up in all infectious disease centers in the Calabria Region as at October 2014. All information were recorded in a common electronic database. Not-infectious co-morbidities (such as cardiovascular diseases, bone fractures, diabetes, renal failure and hypertension) were also studied.   Results   548 patients (68% males; 63% aged <50 years) were included in the CalabrHIV cohort. Major risk factors: sexual transmission (49%) and intravenous drug use (34%). 39% patients had HCV and/or HBV co-infection. An high percentage of late presenters was observed (68.4% patients with CD4+ nadir <350/mm3and 38.5% patients with AIDS at baseline). 83% patients on HAART  had actually undetectable HIV-RNA. Hypertension was the most frequent co-morbidity (21.5%). Multi-morbidity was more frequent in >50 years-old patients than in <50 years-old ones (30% vs. 6%; p<0.0001). Co-morbidity was more frequent in HCV and/or HBV co-infected than in HIV mono-infected patients (46.6% vs. 31.7%: p=0.0006).   Conclusion   This cohort presentation study sheds light, for the first time, on HIV patients’ characteristics in the Calabria Region. Despite a small number of officially reported cases, the size of the cohort was substantial. We showed that HIV infected patients with chronic hepatites, were affected by concomitant not-infectious co-morbidities more than the HIV mono-infected individuals. New HCV treatments are eagerly awaited.