Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
Dilare Adi,
Jialin Abuzhalihan,
Jing Tao,
Yun Wu,
Ying-Hong Wang,
Fen Liu,
Yi-Ning Yang,
Xiang Ma,
Xiao-Mei Li,
Xiang Xie,
Zhen-Yan Fu,
Yi-Tong Ma
Affiliations
Dilare Adi
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Jialin Abuzhalihan
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Jing Tao
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Yun Wu
Department of General Practice, First Affiliated Hospital of Xinjiang Medical University
Ying-Hong Wang
Health Checkup Department of The First Affiliated Hospital of Xinjiang Medical University
Fen Liu
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medical Research Institute, the First Affiliated Hospital of Xinjiang Medical University
Yi-Ning Yang
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Xiang Ma
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Xiao-Mei Li
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Xiang Xie
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Zhen-Yan Fu
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Yi-Tong Ma
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University
Abstract Background Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population in Xinjiang. Methods We designed two independent case–control studies. The first one included in the Han population (448 CAD patients and 343 controls), and the second one is the Uygur population (304 CAD patients and 318 controls). We genotyped three SNPs (rs2072783, rs2205796, and rs909562) of the IDOL gene. Results Our results revealed that, in the Han female subjects, for rs2205796, the distribution of alleles, dominant model (TT vs. GG + GT) and the additive model (GG + TT vs. GT) showed significant differences between CAD patients and the control subjects (P = 0.048, P = 0.014, and P = 0.032, respectively). Conclusions The rs2205796 polymorphism of the IDOL gene is associated with CAD in the Chinese Han female population in Xinjiang, China.
