World Allergy Organization Journal (Oct 2020)
Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)
- Giorgio Walter Canonica,
- Francesco Blasi,
- Pierluigi Paggiaro,
- Gianenrico Senna,
- Giovanni Passalacqua,
- Antonio Spanevello,
- Stefano Aliberti,
- Diego Bagnasco,
- Marco Bonavia,
- Matteo Bonini,
- Luisa Brussino,
- Caterina Bucca,
- Maria F. Caiaffa,
- Cecilia Calabrese,
- Gianna Camiciottoli,
- Marco Caminati,
- Giovanna E. Carpagnano,
- Cristiano Caruso,
- Stefano Centanni,
- Maria E. Conte,
- Angelo G. Corsico,
- Lorenzo Cosmi,
- Maria T. Costantino,
- Nunzio Crimi,
- Simona D’Alò,
- Maria D'Amato,
- Stefano Del Giacco,
- Alessandro Farsi,
- Elisabetta Favero,
- Maria P. Foschino Barbaro,
- Gabriella Guarnieri,
- Giuseppe Guida,
- Manuela Latorre,
- Salvatore Lo Cicero,
- Carlo Lombardi,
- Luigi Macchia,
- Francesco Mazza,
- Francesco Menzella,
- Manlio Milanese,
- Marcello Montagni,
- Paolo Montuschi,
- Eleonora Nucera,
- Roberta Parente,
- Vincenzo Patella,
- Girolamo Pelaia,
- Laura Pini,
- Francesca Puggioni,
- Luisa Ricciardi,
- Fabio L.M. Ricciardolo,
- Luca Richeldi,
- Erminia Ridolo,
- Giovanni Rolla,
- Pierachille Santus,
- Nicola Scichilone,
- Giuseppe Spadaro,
- Andrea Vianello,
- Vittorio Viviano,
- Mona R. Yacoub,
- Maria C. Zappa,
- Enrico Heffler
Affiliations
- Giorgio Walter Canonica
- Personalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy
- Francesco Blasi
- Respiratory Unit and Adult Cystic Fibrosis Center, And Department of Pathophysiology and Transplantation, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Italy
- Pierluigi Paggiaro
- Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Italy
- Gianenrico Senna
- Department of Medicine, Allergy Unit Asthma Center, University of Verona, Italy
- Giovanni Passalacqua
- Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Italy
- Antonio Spanevello
- University of Insubria, ICS Maugeri, IRCCS, Varese, Italy
- Stefano Aliberti
- Respiratory Unit and Adult Cystic Fibrosis Center, And Department of Pathophysiology and Transplantation, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Italy
- Diego Bagnasco
- Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Italy
- Marco Bonavia
- Respiratory Rehabilitation, ASL3, Genoa, Italy
- Matteo Bonini
- Fondazione Policlinico Universitario A. Gemelli, IRCCS Catholic University of Rome, Italy
- Luisa Brussino
- Allergy and Clinical Immunology, University of Turin & AO Mauriziano, Turin, Italy; Respiratory Medicine, Department of Medical Sciences, University of Turin, Italy
- Caterina Bucca
- Allergy and Clinical Immunology, University of Turin & AO Mauriziano, Turin, Italy; Respiratory Medicine, Department of Medical Sciences, University of Turin, Italy
- Maria F. Caiaffa
- Department of Medical Sciences and Surgery, School and Chair of Allergology and Clinical Immunology, University of Foggia, Italy
- Cecilia Calabrese
- Department of Translational Medical Sciences, University of Campania “L. Vanvitelli”, Naples, Italy
- Gianna Camiciottoli
- Deptartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, Respiratory Unit, Careggi University Hospital, Florence, Italy
- Marco Caminati
- Department of Medicine, Allergy Unit Asthma Center, University of Verona, Italy
- Giovanna E. Carpagnano
- Respiratory Medicine Section, Policlinico of Bari, Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy
- Cristiano Caruso
- Allergy Unit, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy
- Stefano Centanni
- Department of Health Sciences, University of Milan, Respiratory Unit, ASST Santi Paolo e Carlo, Milan, Italy
- Maria E. Conte
- Respiratory Unit, Presidio Ospedaliero of Pordenone, Italy
- Angelo G. Corsico
- Division of Respiratory Diseases, IRCCS Policlinico San Matteo, Foundation and Department of Internal Medicine and Therapeutics, University of Pavia, Italy
- Lorenzo Cosmi
- Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
- Maria T. Costantino
- Allergy and Clinical Immunology Unit, Department of Medicine, “Carlo Poma” Hospital, Mantova, Italy
- Nunzio Crimi
- Division of Pneumology and Allergology, Policlinico, University of Catania, Italy
- Simona D’Alò
- Allergology Unit, AV3 ASUR Marche, Hospital Civitanova Marche, Macerata, Italy
- Maria D'Amato
- Respiratory Department, Division of Respiratory Diseases “Federico II” University, AO Dei Colli, Naples, Italy
- Stefano Del Giacco
- Department of Medical Sciences and Public Health, University of Cagliari, Italy
- Alessandro Farsi
- SOS of Allergology and Clinical Immunology, Azienda USL Toscana Centro, Prato, Italy
- Elisabetta Favero
- Severe Asthma Multidisciplinary Outpatient Clinic, Vittorio Veneto Hospital, Treviso, Italy
- Maria P. Foschino Barbaro
- Section of Respiratory Diseases, Medical and Surgical Sciences Department, University of Foggia, Italy
- Gabriella Guarnieri
- Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Italy
- Giuseppe Guida
- Allergy and Pneumology Unit, A.O. S. Croce & Carle, Cuneo, Italy
- Manuela Latorre
- Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Italy
- Salvatore Lo Cicero
- Department of Pneumology, Niguarda Hospital, Milan, Italy
- Carlo Lombardi
- Departmental Unit of Allergology and Pneumology, Hospital Institute Fondazione Poliambulanza, Brescia, Italy
- Luigi Macchia
- Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Italy
- Francesco Mazza
- Respiratory Unit, Presidio Ospedaliero of Pordenone, Italy
- Francesco Menzella
- Pneumology Unit, Santa Maria Nuova Hospital, Azienda USL di Reggio Emilia IRCCS, Italy
- Manlio Milanese
- Pulmonology Unit, ASL2 Savonese, Pietra Ligure, Savona, Italy
- Marcello Montagni
- UOC Allergology Department, Piacenza, Italy
- Paolo Montuschi
- Department of Pharmacology, Faculty of Medicine Catholic, University of the Sacred Heart Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- Eleonora Nucera
- Catholic University S. Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- Roberta Parente
- Department of Medicine, Division of Allergy and Clinical Immunology, University of Salerno, Italy
- Vincenzo Patella
- Allergology and Clinical Immunology Unit, Department of Medical Science, “Santa Maria Della Speranza” Hospital of Battipaglia, Salerno, Italy
- Girolamo Pelaia
- Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University Magna Graecia, Catanzaro, Italy
- Laura Pini
- Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili, Brescia, Italy
- Francesca Puggioni
- Personalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy
- Luisa Ricciardi
- Allergy and Clinical Immunology Unit, University Hospital “G. Martino”, Department of Clinical and Experimental Medicine, University of Messina, Italy
- Fabio L.M. Ricciardolo
- Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
- Luca Richeldi
- Fondazione Policlinico Universitario A. Gemelli, IRCCS Catholic University of Rome, Italy
- Erminia Ridolo
- Department of Medicine and Surgery, University of Parma, Italy
- Giovanni Rolla
- Allergy and Clinical Immunology, University of Turin & AO Mauriziano, Turin, Italy; Respiratory Medicine, Department of Medical Sciences, University of Turin, Italy
- Pierachille Santus
- Department of Clinical and Biomedical Sciences, University of Milan, Respiratory Diseases, Sacco University Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy
- Nicola Scichilone
- Division of Respiratory Diseases, Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D'Alessandro, University of Palermo, Palermo, Italy
- Giuseppe Spadaro
- Department of Internal Medicine, Clinical Immunology, Clinical Pathology and Infectious Diseases, Azienda Ospedaliera Universitaria Federico II, Naples, Italy
- Andrea Vianello
- Division of Respiratory Pathophysiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Italy
- Vittorio Viviano
- Allergology, Pneumology and Respiratory Department 42 PTA Biondo-Regional Center for Allergy Prevention and Anaphylactic Shock, Palermo, Italy
- Mona R. Yacoub
- Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
- Maria C. Zappa
- Pulmonology Department, Sandro Pertini Hospital, Rome, Italy
- Enrico Heffler
- Personalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; Corresponding author. Personalized Medicine, Asthma and Allergy, Istituto Clinico Humanitas, Via Alessandro Manzoni 56, 20089, Rozzano, (MI), Italy.
- Journal volume & issue
-
Vol. 13,
no. 10
p. 100464
Abstract
According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.
