High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis

Abstract

Balancing high resolution and broad genome coverage in single-cell Hi-C approaches remains challenging. Here, the authors describe a computational method for the reconstruction of a large 3D-ensemble of single-cell chromatin conformations from population Hi-C measurements and apply this model to study embryogenesis in D r o s o p h i l a.