Nature Communications (Aug 2021)
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
- Simone Di Franco,
- Paola Bianca,
- Davide Stefano Sardina,
- Alice Turdo,
- Miriam Gaggianesi,
- Veronica Veschi,
- Annalisa Nicotra,
- Laura Rosa Mangiapane,
- Melania Lo Iacono,
- Irene Pillitteri,
- Sander van Hooff,
- Federica Martorana,
- Gianmarco Motta,
- Eliana Gulotta,
- Vincenzo Luca Lentini,
- Emanuele Martorana,
- Micol Eleonora Fiori,
- Salvatore Vieni,
- Maria Rita Bongiorno,
- Giorgio Giannone,
- Dario Giuffrida,
- Lorenzo Memeo,
- Lorenzo Colarossi,
- Marzia Mare,
- Paolo Vigneri,
- Matilde Todaro,
- Ruggero De Maria,
- Jan Paul Medema,
- Giorgio Stassi
Affiliations
- Simone Di Franco
- Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo
- Paola Bianca
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo
- Davide Stefano Sardina
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo
- Alice Turdo
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo
- Miriam Gaggianesi
- Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo
- Veronica Veschi
- Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo
- Annalisa Nicotra
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo
- Laura Rosa Mangiapane
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo
- Melania Lo Iacono
- Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo
- Irene Pillitteri
- Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo
- Sander van Hooff
- Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam
- Federica Martorana
- Department of Clinical and Experimental Medicine, A.O.U. Policlinico-Vittorio Emanuele, Division of Medical Oncology, University of Catania
- Gianmarco Motta
- Department of Clinical and Experimental Medicine, A.O.U. Policlinico-Vittorio Emanuele, Division of Medical Oncology, University of Catania
- Eliana Gulotta
- Reconstructive Plastic Surgery, ARNAS Ospedali Civico Di Cristina e Benfratelli
- Vincenzo Luca Lentini
- Pathology Unit, Ospedali Riuniti Villa Sofia-Cervello
- Emanuele Martorana
- IOM (Mediterranean Institute of Oncology) Ricerca, Viagrande
- Micol Eleonora Fiori
- Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità
- Salvatore Vieni
- Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo
- Maria Rita Bongiorno
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo
- Giorgio Giannone
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Dario Giuffrida
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Lorenzo Memeo
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Lorenzo Colarossi
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Marzia Mare
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Paolo Vigneri
- Department of Clinical and Experimental Medicine, A.O.U. Policlinico-Vittorio Emanuele, Center of Experimental Oncology and Hematology, University of Catania
- Matilde Todaro
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo
- Ruggero De Maria
- Istituto di Patologia Generale, Università Cattolica del Sacro Cuore
- Jan Paul Medema
- Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam
- Giorgio Stassi
- Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo
- DOI
- https://doi.org/10.1038/s41467-021-25333-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Obesity is a major risk factor for cancer related death. Here, the authors show that visceral adipose-derived factors promote vasculogenesis and metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
