Nature Communications (Aug 2021)

NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation

  • Huibing Wang,
  • Weiwei Qi,
  • Chengyu Zou,
  • Zhangdan Xie,
  • Mengmeng Zhang,
  • Masanori Gomi Naito,
  • Lauren Mifflin,
  • Zhen Liu,
  • Ayaz Najafov,
  • Heling Pan,
  • Bing Shan,
  • Ying Li,
  • Zheng-Jiang Zhu,
  • Junying Yuan

DOI
https://doi.org/10.1038/s41467-021-25157-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism to neuroinflammation by dietary intervention.