Nature Communications (Apr 2023)
Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication
- Yanling Liu,
- Jonathon Klein,
- Richa Bajpai,
- Li Dong,
- Quang Tran,
- Pandurang Kolekar,
- Jenny L. Smith,
- Rhonda E. Ries,
- Benjamin J. Huang,
- Yi-Cheng Wang,
- Todd A. Alonzo,
- Liqing Tian,
- Heather L. Mulder,
- Timothy I. Shaw,
- Jing Ma,
- Michael P. Walsh,
- Guangchun Song,
- Tamara Westover,
- Robert J. Autry,
- Alexander M. Gout,
- David A. Wheeler,
- Shibiao Wan,
- Gang Wu,
- Jun J. Yang,
- William E. Evans,
- Mignon Loh,
- John Easton,
- Jinghui Zhang,
- Jeffery M. Klco,
- Soheil Meshinchi,
- Patrick A. Brown,
- Shondra M. Pruett-Miller,
- Xiaotu Ma
Affiliations
- Yanling Liu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jonathon Klein
- Department of Cell and Molecular Biology and Center for Advanced Genome Editing, St. Jude Children’s Research Hospital
- Richa Bajpai
- Department of Cell and Molecular Biology and Center for Advanced Genome Editing, St. Jude Children’s Research Hospital
- Li Dong
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Quang Tran
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Pandurang Kolekar
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jenny L. Smith
- Clinical Research Division, Fred Hutchinson Cancer Research Center
- Rhonda E. Ries
- Clinical Research Division, Fred Hutchinson Cancer Research Center
- Benjamin J. Huang
- Department of Pediatrics and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
- Yi-Cheng Wang
- Children’s Oncology Group
- Todd A. Alonzo
- Department of Preventive Medicine, University of Southern California
- Liqing Tian
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Heather L. Mulder
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Timothy I. Shaw
- Department of Biostatistics and Bioinformatics, Moffitt Cancer Center
- Jing Ma
- Department of Pathology, St. Jude Children’s Research Hospital
- Michael P. Walsh
- Department of Pathology, St. Jude Children’s Research Hospital
- Guangchun Song
- Department of Pathology, St. Jude Children’s Research Hospital
- Tamara Westover
- Department of Pathology, St. Jude Children’s Research Hospital
- Robert J. Autry
- Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- Alexander M. Gout
- Department of Computational Biology, St. Jude Children’s Research Hospital
- David A. Wheeler
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Shibiao Wan
- Center for Applied Bioinformatics, St. Jude Children’s Research Hospital
- Gang Wu
- Center for Applied Bioinformatics, St. Jude Children’s Research Hospital
- Jun J. Yang
- Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- William E. Evans
- Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital
- Mignon Loh
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute and the Department of Pediatrics, Seattle Children’s Hospital, University of Washington
- John Easton
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jinghui Zhang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jeffery M. Klco
- Department of Pathology, St. Jude Children’s Research Hospital
- Soheil Meshinchi
- Clinical Research Division, Fred Hutchinson Cancer Research Center
- Patrick A. Brown
- Bristol Myers Squibb
- Shondra M. Pruett-Miller
- Department of Cell and Molecular Biology and Center for Advanced Genome Editing, St. Jude Children’s Research Hospital
- Xiaotu Ma
- Department of Computational Biology, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-023-37438-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, their links with tumor progression and evolution, and their potential as therapeutic targets.
