mSystems
(Jun 2021)
Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome
Celeste Allaband,
Amulya Lingaraju,
Cameron Martino,
Baylee Russell,
Anupriya Tripathi,
Orit Poulsen,
Ana Carolina Dantas Machado,
Dan Zhou,
Jin Xue,
Emmanuel Elijah,
Atul Malhotra,
Pieter C. Dorrestein,
Rob Knight,
Gabriel G. Haddad,
Amir Zarrinpar
Affiliations
Celeste Allaband
ORCiD Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Amulya Lingaraju
Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Cameron Martino
ORCiD Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Baylee Russell
Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Anupriya Tripathi
Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Orit Poulsen
Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Ana Carolina Dantas Machado
Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Dan Zhou
Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Jin Xue
Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Emmanuel Elijah
Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California, USA
Atul Malhotra
Center for Circadian Biology, University of California, San Diego, La Jolla, California, USA
Pieter C. Dorrestein
Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA
Rob Knight
ORCiD Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA
Gabriel G. Haddad
Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA
Amir Zarrinpar
ORCiD Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
DOI
https://doi.org/10.1128/mSystems.00116-21
Journal volume & issue
Vol. 6,
no. 3
Abstract
Read online
People with obstructive sleep apnea, identified by loud snoring and breathing irregularly while sleeping, are at a higher risk of high blood pressure, type 2 diabetes, cardiac arrhythmias, stroke, and sudden cardiac death. We wanted to understand whether the gut microbiome changes induced by obstructive sleep apnea could potentially explain some of these medical problems.
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