Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome

Celeste Allaband; Amulya Lingaraju; Cameron Martino; Baylee Russell; Anupriya Tripathi; Orit Poulsen; Ana Carolina Dantas Machado; Dan Zhou; Jin Xue; Emmanuel Elijah; Atul Malhotra; Pieter C. Dorrestein; Rob Knight; Gabriel G. Haddad; Amir Zarrinpar

doi:10.1128/mSystems.00116-21

mSystems (Jun 2021)

Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome

Celeste Allaband,
Amulya Lingaraju,
Cameron Martino,
Baylee Russell,
Anupriya Tripathi,
Orit Poulsen,
Ana Carolina Dantas Machado,
Dan Zhou,
Jin Xue,
Emmanuel Elijah,
Atul Malhotra,
Pieter C. Dorrestein,
Rob Knight,
Gabriel G. Haddad,
Amir Zarrinpar

Affiliations

Celeste Allaband: ORCiD; Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Amulya Lingaraju: Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Cameron Martino: ORCiD; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Baylee Russell: Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Anupriya Tripathi: Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Orit Poulsen: Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Ana Carolina Dantas Machado: Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
Dan Zhou: Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Jin Xue: Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
Emmanuel Elijah: Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California, USA
Atul Malhotra: Center for Circadian Biology, University of California, San Diego, La Jolla, California, USA
Pieter C. Dorrestein: Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA
Rob Knight: ORCiD; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA
Gabriel G. Haddad: Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA
Amir Zarrinpar: ORCiD; Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA

DOI: https://doi.org/10.1128/mSystems.00116-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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People with obstructive sleep apnea, identified by loud snoring and breathing irregularly while sleeping, are at a higher risk of high blood pressure, type 2 diabetes, cardiac arrhythmias, stroke, and sudden cardiac death. We wanted to understand whether the gut microbiome changes induced by obstructive sleep apnea could potentially explain some of these medical problems.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

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