Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

Dahai Yang; Xin Zheng; Shouwen Chen; Zhuang Wang; Wenting Xu; Jinchao Tan; Tianjian Hu; Mingyu Hou; Wenhui Wang; Zhaoyan Gu; Qiyao Wang; Ruilin Zhang; Yuanxing Zhang; Qin Liu

doi:10.1038/s41467-018-04984-1

Nature Communications (Aug 2018)

Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

Dahai Yang,
Xin Zheng,
Shouwen Chen,
Zhuang Wang,
Wenting Xu,
Jinchao Tan,
Tianjian Hu,
Mingyu Hou,
Wenhui Wang,
Zhaoyan Gu,
Qiyao Wang,
Ruilin Zhang,
Yuanxing Zhang,
Qin Liu

Affiliations

Dahai Yang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Xin Zheng: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Shouwen Chen: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Zhuang Wang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Wenting Xu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Jinchao Tan: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Tianjian Hu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Mingyu Hou: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Wenhui Wang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Zhaoyan Gu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Qiyao Wang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Ruilin Zhang: Shanghai Collaborative Innovation Center for Biomanufacturing
Yuanxing Zhang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Qin Liu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology

DOI: https://doi.org/10.1038/s41467-018-04984-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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In humans, caspase-5 is an LPS sensor that can induce gasdermin D cleavage and pyroptosis. Here, the authors show that zebrafish caspy2 is a functional homolog as it also senses cytosolic LPS to activate the noncanonical inflammasome and to protect against bacterial infection, but it does so via pyrin death domain interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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