Synthesis, Characterization and DNA binding studies of Platinum Complexes with Imine Ferrocene Ligand

Abstract

In this manuscript,, the synthesis and characterization by NMR spectroscopy of the two novel platinum complexes with the imine ferocene with different coordination mode to platinum center, Pt(Cl)2(dmso)(Imine) (1) and Pt(Me)(dmso)(Imine) (2) was introduced , in which the ligand was attached as the monodentate ligand in (1) and in (2) the ligand was attached as the cyclomatalated bidentate ligand , were introduced for checking their anticancer properties. Also their interaction waith DNA was studied by UV-Vis titration technique. In addition, Molecular docking simulation by Schrödinger sofware was used for checking the various possible attachment mode of their interaction with DNA.

Keywords

• platinum
• ferrocene
• complex
• dna