Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

Abstract

In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.

Keywords

• Cancer immunotherapy
• microbiota
• immunosuppression
• MAdCAM-1
• bile acids
• Enterocloster