COMPREHENSIVE EVALUATION OF VARIABILITY IN ARTERIAL HYPERTENSION WITH DIFFERENT BODY WEIGHT

Abstract

The study aimed to build a diagnostic model of formation of a group of hypertensive patients with different bodyweight based on the results of the evaluation of the variability of quantitative and qualitative indicators of influence. 300 patients with AH aged 45 to 55 who gave informed written consent to participate in the study and met the inclusion criteria were examined. Group 1 consisted of 200 patients with AH and obesity I-II classes, group 2 – 50 patients with AH and normal body weight, group 3 – 50 patients with AH and overweight. In the factor analysis of the group of hypertensive patients 4 factors were found. Those factors explained 23.32% of the variability of the indicators: «anthropometric-metabolic-endothelial factor», «systolic factor», «hemodynamic factor» and «insulin-resistance-diastolic factor». The data of the logistic regression method showed that the formation of a group of hypertensive patients with different body weight was influenced by anthropometric indicators (BMI), metabolic indicators (HOMA index, adiponectin), RAAS activity (aldosterone and ARC), systolic (EF and SV) and diastolic cardiac function (MV E, e f and E/e), as well as ADIPOQ genetic polymorphism.

Keywords

• hypertension
• obesity
• diagnostic model
• factor analysis
• logistic regression