An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

Gabriela Dias Noske; Yun Song; Rafaela Sachetto Fernandes; Rod Chalk; Haitem Elmassoudi; Lizbé Koekemoer; C. David Owen; Tarick J. El-Baba; Carol V. Robinson; The COVID Moonshot Consortium; Glaucius Oliva; Andre Schutzer Godoy

doi:10.1038/s41467-023-37035-5

Nature Communications (Mar 2023)

An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

Gabriela Dias Noske,
Yun Song,
Rafaela Sachetto Fernandes,
Rod Chalk,
Haitem Elmassoudi,
Lizbé Koekemoer,
C. David Owen,
Tarick J. El-Baba,
Carol V. Robinson,
The COVID Moonshot Consortium,
Glaucius Oliva,
Andre Schutzer Godoy

Affiliations

Gabriela Dias Noske: Sao Carlos Institute of Physics, University of Sao Paulo, Av. Joao Dagnone
Yun Song: Electron Bio-imaging Centre, Diamond Light Source Ltd., Harwell Science and Innovation Campus
Rafaela Sachetto Fernandes: Sao Carlos Institute of Physics, University of Sao Paulo, Av. Joao Dagnone
Rod Chalk: Centre for Medicines Discovery, Oxford University
Haitem Elmassoudi: Centre for Medicines Discovery, Oxford University
Lizbé Koekemoer: Centre for Medicines Discovery, Oxford University
C. David Owen: Electron Bio-imaging Centre, Diamond Light Source Ltd., Harwell Science and Innovation Campus
Tarick J. El-Baba: Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford
Carol V. Robinson: Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford
The COVID Moonshot Consortium
Glaucius Oliva: Sao Carlos Institute of Physics, University of Sao Paulo, Av. Joao Dagnone
Andre Schutzer Godoy: Sao Carlos Institute of Physics, University of Sao Paulo, Av. Joao Dagnone

DOI: https://doi.org/10.1038/s41467-023-37035-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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The Main protease of SARS-CoV-2 is key for viral replication, but its maturation process is still not completely understood. Here, the authors not only reveal unique details from the first step of maturation, but also demonstrate how different classes of inhibitor can block this step.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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