Diabetes, Metabolic Syndrome and Obesity (Dec 2022)

Association Between Coronary Artery Calcium Score and Bone Mineral Density in Type 2 Diabetes Mellitus with Different Visceral Fat Area

  • Yang Y,
  • Li L,
  • Zhang Y,
  • Yang H,
  • Bai J,
  • Lv H,
  • Fu S

Journal volume & issue
Vol. Volume 15
pp. 3949 – 3960

Abstract

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Ying Yang,1,2 Lingling Li,1,2 Yangyang Zhang,1,2 Hong Yang,1,2 Jia Bai,1,2 Haihong Lv,1,2 Songbo Fu1,2 1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China; 2The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of ChinaCorrespondence: Haihong Lv; Songbo Fu, Department of Endocrinology, The First Hospital of Lanzhou University, No. 1Donggang West Road, Lanzhou, Gansu, 730000, People’s Republic of China, Tel +86 13893324091 ; +86 13993122257, Email [email protected]; [email protected]: The relationship between coronary artery calcification and bone mineral density (BMD) in T2DM is still unclear. The aim of this study is to analyze the association between coronary artery calcium score (CACs) and BMD in T2DM with different visceral fat area (VFA), and further to explore the clinical significance of CACs in predicting osteoporosis in T2DM patients.Patients and Methods: A total of 479 T2DM patients aged ≥ 50 years were included. Agatston was applied to calculate CACs to evaluate the degree of coronary artery calcification. Dual-energy X-ray absorptiometry (DXA) was used to measure BMD. According to VFA, all subjects were divided into VFA 0.05). However, CACs was negatively associated with BMD of total hip and lumbar spine in patients with VFA ≥ 100cm2 (total hip β=− 0.087 p=0.01; lumbar spine β=− 0.052 p=0.005), but not VFA < 100cm2. ROC curve analysis showed that the optimal cut-off value of CACs for screening osteoporosis was 191.505.Conclusion: The present study implied that associations between CACs and BMD varied by the visceral fat deposition. It is critical to evaluate the condition of visceral fat accumulation for exploring the complex interplay of coronary artery calcification and BMD in T2DM patients. It may be of some clinical value for CACs in predicting osteoporosis in T2DM with visceral obesity.Keywords: bone mineral density, coronary artery calcium score, type 2 diabetes mellitus, visceral fat area

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