Nature Communications (Sep 2021)
Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
Abstract
Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating its therapeutic potential in vitro and in vivo.