Nature Communications (Sep 2021)

Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies

  • Guy Biber,
  • Aviad Ben-Shmuel,
  • Elad Noy,
  • Noah Joseph,
  • Abhishek Puthenveetil,
  • Neria Reiss,
  • Omer Levy,
  • Itay Lazar,
  • Ariel Feiglin,
  • Yanay Ofran,
  • Meirav Kedmi,
  • Abraham Avigdor,
  • Sophia Fried,
  • Mira Barda-Saad

DOI
https://doi.org/10.1038/s41467-021-25842-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating its therapeutic potential in vitro and in vivo.