Two-photon fluorescence imaging and specifically biosensing of norepinephrine on a 100-ms timescale

Leiwen Mao; Yujie Han; Qi-Wei Zhang; Yang Tian

doi:10.1038/s41467-023-36869-3

Nature Communications (Mar 2023)

Two-photon fluorescence imaging and specifically biosensing of norepinephrine on a 100-ms timescale

Leiwen Mao,
Yujie Han,
Qi-Wei Zhang,
Yang Tian

Affiliations

Leiwen Mao: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University
Yujie Han: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University
Qi-Wei Zhang: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University
Yang Tian: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University

DOI: https://doi.org/10.1038/s41467-023-36869-3
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

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Norepinephrine (NE) is a key neurotransmitter in the central nervous system of organisms however specifically tracking the transient NE dynamics with high spatiotemporal resolution in living systems remains a great challenge. Herein, the authors developed a small molecular fluorescent probe that can precisely anchor on neuronal cytomembranes and specifically respond to NE on a 100-ms timescale.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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