Pre-biopsy modelling of condition of germinogenic epithelium in azoospermia using endocrine and genetic predictors

Abstract

OBJECTIVE. The study revealed clinical, endocrine and genetical predictors of safety of spermatogenic epithelium in patients with nonobstructive azoospermia. MATERIAL AND METHODS. The open testicular biopsy was performed in 38 patients with secretory azoospermia. The wide range of instrumental, laboratory studies were conducted before biopsy. RESULTS. Two prognostic models were developed by taking into account the revealed predictors of damage of germinogenic epithelium. CONCLUSIONS. The age, concentration of follicle-stimulating hormone, presence or absence of microdeletion AZFc are independent prognostic predictors of germinal epithelium condition.

Keywords

• azfc
• azoospermia
• follicle-stimulating hormone
• azfc
• open testicular biopsy
• age