Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies

Zhujun Mei; Zhujun Mei; Zhujun Mei; Zhujun Mei; Jingguo Wang; Jingguo Wang; Junling Wang; Xiaoni Liu; Xiaoni Liu; Bo Deng; Bo Deng; Wenbo Yang; Wenbo Yang; Xiang Zhang; Xiang Zhang; Xiangjun Chen; Xiangjun Chen; Hai Yu; Hai Yu

doi:10.3389/fimmu.2024.1461024

Frontiers in Immunology (Jan 2025)

Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies

Zhujun Mei,
Zhujun Mei,
Zhujun Mei,
Zhujun Mei,
Jingguo Wang,
Jingguo Wang,
Junling Wang,
Xiaoni Liu,
Xiaoni Liu,
Bo Deng,
Bo Deng,
Wenbo Yang,
Wenbo Yang,
Xiang Zhang,
Xiang Zhang,
Xiangjun Chen,
Xiangjun Chen,
Hai Yu,
Hai Yu

Affiliations

Zhujun Mei: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Zhujun Mei: Department of Neurology, National Center for Neurological Disorders, Shanghai, China
Zhujun Mei: Department of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases), Nanchang, Jiangxi, China
Zhujun Mei: Jiangxi Provincial People’s Hospital, Clinical College of Nanchang Medical College, First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
Jingguo Wang: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Jingguo Wang: Department of Neurology, National Center for Neurological Disorders, Shanghai, China
Junling Wang: Department of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases), Nanchang, Jiangxi, China
Xiaoni Liu: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Xiaoni Liu: Department of Neurology, National Center for Neurological Disorders, Shanghai, China
Bo Deng: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Bo Deng: Department of Neurology, National Center for Neurological Disorders, Shanghai, China
Wenbo Yang: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Wenbo Yang: Department of Neurology, National Center for Neurological Disorders, Shanghai, China
Xiang Zhang: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Xiang Zhang: Department of Neurology, National Center for Neurological Disorders, Shanghai, China
Xiangjun Chen: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Xiangjun Chen: Department of Neurology, National Center for Neurological Disorders, Shanghai, China
Hai Yu: Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China
Hai Yu: Department of Neurology, National Center for Neurological Disorders, Shanghai, China

DOI: https://doi.org/10.3389/fimmu.2024.1461024
Journal volume & issue: Vol. 15

Abstract

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We report a case of optic neuritis (ON) secondary to autoimmune encephalitis (AE) in a patient with concomitant antibodies to N-methyl-D-aspartate receptor (NMDAR), gamma-aminobutyric acid-B receptor (GABABR), and myelin oligodendrocyte glycoprotein (MOG). The patient exhibited a constellation of symptoms, including vision loss, seizures, mental and behavioral disorders, cognitive impairment, and speech abnormalities. At the two-year follow-up, the patient’s symptoms had abated entirely. Overlap syndrome of triple autoimmune antibodies is rare and the coexistence of antibodies to NMDAR, GABABR and MOG has not been reported till now. This case report provides novel experience of diagnosis and treatment in autoimmune overlap syndromes.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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