Nature Communications (2019-01-01)

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

  • Longqi Liu,
  • Chuanyu Liu,
  • Andrés Quintero,
  • Liang Wu,
  • Yue Yuan,
  • Mingyue Wang,
  • Mengnan Cheng,
  • Lizhi Leng,
  • Liqin Xu,
  • Guoyi Dong,
  • Rui Li,
  • Yang Liu,
  • Xiaoyu Wei,
  • Jiangshan Xu,
  • Xiaowei Chen,
  • Haorong Lu,
  • Dongsheng Chen,
  • Quanlei Wang,
  • Qing Zhou,
  • Xinxin Lin,
  • Guibo Li,
  • Shiping Liu,
  • Qi Wang,
  • Hongru Wang,
  • J. Lynn Fink,
  • Zhengliang Gao,
  • Xin Liu,
  • Yong Hou,
  • Shida Zhu,
  • Huanming Yang,
  • Yunming Ye,
  • Ge Lin,
  • Fang Chen,
  • Carl Herrmann,
  • Roland Eils,
  • Zhouchun Shang,
  • Xun Xu

DOI
https://doi.org/10.1038/s41467-018-08205-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Heterogeneity in gene expression and epigenetic states exists across individual cells. Here, the authors develop scCAT-seq, a technique for simultaneously performing ATAC-seq and RNA-seq within the same single cell.