Nature Communications (May 2021)
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
- Benjamin Compans,
- Come Camus,
- Emmanouela Kallergi,
- Silvia Sposini,
- Magalie Martineau,
- Corey Butler,
- Adel Kechkar,
- Remco V. Klaassen,
- Natacha Retailleau,
- Terrence J. Sejnowski,
- August B. Smit,
- Jean-Baptiste Sibarita,
- Thomas M. Bartol,
- David Perrais,
- Vassiliki Nikoletopoulou,
- Daniel Choquet,
- Eric Hosy
Affiliations
- Benjamin Compans
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Come Camus
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Emmanouela Kallergi
- Department of Fundamental Neurosciences, University of Lausanne
- Silvia Sposini
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Magalie Martineau
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Corey Butler
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Adel Kechkar
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Remco V. Klaassen
- Department Molecular and Cellular Neurobiology
- Natacha Retailleau
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Terrence J. Sejnowski
- Howard Hughes Medical Institute, Salk Institute for Biological Studies
- August B. Smit
- Department Molecular and Cellular Neurobiology
- Jean-Baptiste Sibarita
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Thomas M. Bartol
- Howard Hughes Medical Institute, Salk Institute for Biological Studies
- David Perrais
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Vassiliki Nikoletopoulou
- Department of Fundamental Neurosciences, University of Lausanne
- Daniel Choquet
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- Eric Hosy
- Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297
- DOI
- https://doi.org/10.1038/s41467-021-23133-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to specific modification of synapse function.
