Multifunctional synthetic nano-chaperone for peptide folding and intracellular delivery

Il-Soo Park; Seongchan Kim; Yeajee Yim; Ginam Park; Jinahn Choi; Cheolhee Won; Dal-Hee Min

doi:10.1038/s41467-022-32268-2

Nature Communications (Aug 2022)

Multifunctional synthetic nano-chaperone for peptide folding and intracellular delivery

Il-Soo Park,
Seongchan Kim,
Yeajee Yim,
Ginam Park,
Jinahn Choi,
Cheolhee Won,
Dal-Hee Min

Affiliations

Il-Soo Park: Department of Chemistry, Seoul National University
Seongchan Kim: Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST)
Yeajee Yim: Department of Chemistry, Seoul National University
Ginam Park: Department of Chemistry, Seoul National University
Jinahn Choi: Department of Chemistry, Seoul National University
Cheolhee Won: Institute of Biotherapeutics Convergence Technology, Lemonex Inc
Dal-Hee Min: Department of Chemistry, Seoul National University

DOI: https://doi.org/10.1038/s41467-022-32268-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Molecular chaperones play an important part in protein folding and delivery in nature. Here, the authors report on the creation of a synthetic chaperone to control the folding of therapeutic peptides from random coil to alpha helix and demonstrate enhanced therapeutic potential in an in vivo tumour model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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