Longterm physicochemical stability of ready-to-administer human insulin injection solutions 1 I.U./mL in 50 mL plastic syringes

Abstract

The objective of this study was to investigate the physicochemical stability of ready-to-adminster human insulin (HI) 1 I.U./mL injection solutions of two different brand products diluted with 0.9% NaCl solution under different storage conditions either in 50 mL disposable plastic syringes or as bulk solution in infusion bags.

Keywords

• continuous intravenous injection
• eva infusion bag
• human insulin 1 i.u./ml
• physicochemical stability
• plastic syringe
• polyolefin