Zhongguo quanke yixue (Jun 2023)
Impact of Elevated Fasting Blood Glucose on Urodynamic Parameters in Patients with Benign Prostatic Hyperplasia
Abstract
Background Benign prostatic hyperplasia (BPH) is a major cause of lower urinary tract symptoms in middle-aged and elderly men, while abnormal blood glucose can also lead to functional and organic changes in urinary system. However, there is still a lack of relevant research on the effect of abnormal blood glucose on urodynamic parameters of BPH patients. Objective To explore the impact of elevated fasting blood glucose (FBG) on urodynamic parameters of BPH patients. Methods The clinical data of 95 older male patients with BPH who were hospitalized in Department of Urology, Second Affiliated Hospital of Dalian Medical University from January to December, 2021 were analyzed retrospectively. They were divided into hyperglycemic group (n=11) and normal FBG group (n=84) according to the admission FBG level to compare clinical indicators. Results We found that the two groups had no statistically significant differences in average age, BMI, total prostate-specific antigen (tPSA), the volume, length, width and height of the prostate, and glycosylated hemoglobin (P>0.05). It was noticed that the mean course of diabetes in the hyperglycemic group was longer〔2 (0, 10) years vs 0 (0, 0) years, u=705.500, P=0.025〕. The average FBG level of the hyperglycemic group was significantly higher than that of the normal FBG group 〔 (8.9±2.1) mmol/L vs (5.4±0.7) mmol/L, t=-11.263, P<0.001〕. As for urodynamic parameters, the International Prostate Symptom Score (IPSS), IPSS voiding (IPSS-V), quality life (Qol) score, post-voiding residual volume (PVRV), maximum urine flow rate and detrusor pressure at Q-max were similar between the groups (P>0.05). However, the average scores on IPSS-storage〔 (13.7±1.4) scores vs (11.4±3.3) scores, t=-2.316, P=0.023〕 and bladder first sensation volume〔 (147.8±76.9) ml vs (100.2±48.0) ml, t=-2.532, P=0.014〕in the hyperglycemic group were significantly higher. Conclusion We demonstrated that elevated FBG has significant adverse effects on subjective and objective urodynamic parameters of BPH patients, which may lead to impaired first sensation volume of bladder and more severe storage symptoms. These patients often have a long course of diabetes, so more clinical attention should be given to their blood glucose control. It is of prominent significance to take active comprehensive intervention for symptomatic management of BPH.
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