Geriatric Care (Apr 2016)
The effect of erythropoietin on calcium levels during hypoxia reoxygenation injury in rats
Abstract
This experimental study examined the effect of erythropoietin (Epo) on rat model and particularly in a hypoxia-reoxygenation protocol. The effect of that molecule was studied biochemically using blood mean calcium levels (Ca++). Forty rats of mean weight 247.7 g were used in the study. Ca++ levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reoxygenation. Erythropoietin was administered only in groups C and D. Epo administration non-significantly decreased the Ca++ levels by 0.56%±1.13% (P=0.5761). Reoxygenation time non-significantly increased the Ca++ levels by 0.65%±1.12% (P=0.5281). However, Epo administration and reoxygenation time together non-significantly decreased the Ca++ levels by 0.34%±0.68% (P=0.6095). Epo administration whether it interacted or not with reoxygenation time had non-significant decreasing short-term effects on calcium levels. Perhaps, a longer study time than 2 h or a higher Epo dose may reveal more significant effects.
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