Evaluation of the Effects of Increased Parathyroid Hormone (PTH) Following Myocardial Infarction on the Expressions Level of Matrix Metalloproteinase 9 and Tissue Inhibitor Metalloproteinase

Abstract

Background: Myocardial infarction (MI) is one of the most important health problems around the world. Increased parathyroid hormone (PTH) following MI causes significant improvement in myocardial performance. On the other hand, the imbalance between matrix metalloproteinases (MMPs) and tissue inhibitor metalloproteinases (TIMPs) causes major health problems like sudden cardiac death. In this study, we tried to investigate the correlation between serum post-MI PTH levels with MMP-9 or TIMP-1. Methods: 62 patients diagnosed with MI were enrolled the study between 2016 and 2017 as well as 6 normal persons as control group. Blood sample was collected 72 hours after MI and serum was separated. Serum levels of TIMP-1, MMP-9, and PTH were measured using the enzyme-linked immunosorbent assay (ELISA) assay kit. Findings: The serum levels of MMP-9 (8.07 ± 4.30 ng/ml) and PTH (61.94 ± 40.44 pg/ml) were significantly increased versus the control group (2.83 ± 0.44 ng/ml and 30.93 ± 6.59 pg/ml, respectively). The serum level of TIMP-1 (6.21 ± 1.36 ng/ml) increased compared to the control group (5.60 ± 0.57 ng/ml), but the difference between them was not statistically significant. In total, statistical analysis showed that there was no significant correlation between the increased level of serum PTH with those of MMP-9 or TIMP-1. Conclusion: These results proposed that PTH and MMP-9 or TIMP-1 are independent factors in post-MI events.

Keywords

• Myocardial infarction
• Matrix metalloproteinases
• Tissue inhibitor of metalloproteinases
• Parathyroid hormone