Hybprinting for musculoskeletal tissue engineering

Jiannan Li; Carolyn Kim; Chi-Chun Pan; Aaron Babian; Elaine Lui; Jeffrey L. Young; Seyedsina Moeinzadeh; Sungwoo Kim; Yunzhi Peter Yang

iScience (May 2022)

Hybprinting for musculoskeletal tissue engineering

Jiannan Li,
Carolyn Kim,
Chi-Chun Pan,
Aaron Babian,
Elaine Lui,
Jeffrey L. Young,
Seyedsina Moeinzadeh,
Sungwoo Kim,
Yunzhi Peter Yang

Affiliations

Jiannan Li: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA
Carolyn Kim: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA; Department of Mechanical Engineering, 416 Escondido Mall, Stanford University, Stanford, CA 94305, USA
Chi-Chun Pan: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA; Department of Mechanical Engineering, 416 Escondido Mall, Stanford University, Stanford, CA 94305, USA
Aaron Babian: Department of Biological Sciences, University of California, Davis CA 95616, USA
Elaine Lui: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA; Department of Mechanical Engineering, 416 Escondido Mall, Stanford University, Stanford, CA 94305, USA
Jeffrey L. Young: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA
Seyedsina Moeinzadeh: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA
Sungwoo Kim: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA
Yunzhi Peter Yang: Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA; Department of Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA 94305, USA; Corresponding author

Journal volume & issue: Vol. 25, no. 5
p. 104229

Abstract

Read online

Summary: This review presents bioprinting methods, biomaterials, and printing strategies that may be used for composite tissue constructs for musculoskeletal applications. The printing methods discussed include those that are suitable for acellular and cellular components, and the biomaterials include soft and rigid components that are suitable for soft and/or hard tissues. We also present strategies that focus on the integration of cell-laden soft and acellular rigid components under a single printing platform. Given the structural and functional complexity of native musculoskeletal tissue, we envision that hybrid bioprinting, referred to as hybprinting, could provide unprecedented potential by combining different materials and bioprinting techniques to engineer and assemble modular tissues.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

About the journal

Abstract

Keywords