(-)-Epigallocatechin-3-Gallate (EGCG) Modulates the Composition of the Gut Microbiota to Protect Against Radiation-Induced Intestinal Injury in Mice

Shang Cai; Shang Cai; Li-Wei Xie; Li-Wei Xie; Jia-Yu Xu; Jia-Yu Xu; Hao Zhou; Chao Yang; Lin-Feng Tang; Ye Tian; Ye Tian; Ming Li

doi:10.3389/fonc.2022.848107

Frontiers in Oncology (Apr 2022)

(-)-Epigallocatechin-3-Gallate (EGCG) Modulates the Composition of the Gut Microbiota to Protect Against Radiation-Induced Intestinal Injury in Mice

Shang Cai,
Shang Cai,
Li-Wei Xie,
Li-Wei Xie,
Jia-Yu Xu,
Jia-Yu Xu,
Hao Zhou,
Chao Yang,
Lin-Feng Tang,
Ye Tian,
Ye Tian,
Ming Li

Affiliations

Shang Cai: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
Shang Cai: Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
Li-Wei Xie: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
Li-Wei Xie: Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
Jia-Yu Xu: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
Jia-Yu Xu: Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
Hao Zhou: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China
Chao Yang: Department of Nucleus Radiation-related Injury Treatment, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China
Lin-Feng Tang: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China
Ye Tian: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
Ye Tian: Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
Ming Li: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China

DOI: https://doi.org/10.3389/fonc.2022.848107
Journal volume & issue: Vol. 12

Abstract

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The high radiosensitivity of the intestinal epithelium limits the outcomes of radiotherapy against abdominal malignancies, which results in poor prognosis. Currently, no effective prophylactic or therapeutic strategy is available to mitigate radiation toxicity in the intestine. Our previous study revealed that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) attenuates radiation-induced intestinal injury (RIII). The aim of the present study was to determine the effect of EGCG on the intestinal flora of irradiated mice. EGCG administration reduced radiation-induced intestinal mucosal injury, and significantly increased the number of Lgr5+ intestinal stem cells (ISCs) and Ki67+ crypt cells. In addition, EGCG reversed radiation-induced gut dysbiosis, restored the Firmicutes/Bacteroidetes ratio, and increased the abundance of beneficial bacteria. Our findings provide novel insight into EGCG-mediated remission of RIII, revealing that EGCG could be a potential modulator of gut microbiota to prevent and treat RIII.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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