Nature Communications (Aug 2019)
A meta-analysis of genome-wide association studies identifies multiple longevity genes
- Joris Deelen,
- Daniel S. Evans,
- Dan E. Arking,
- Niccolò Tesi,
- Marianne Nygaard,
- Xiaomin Liu,
- Mary K. Wojczynski,
- Mary L. Biggs,
- Ashley van der Spek,
- Gil Atzmon,
- Erin B. Ware,
- Chloé Sarnowski,
- Albert V. Smith,
- Ilkka Seppälä,
- Heather J. Cordell,
- Janina Dose,
- Najaf Amin,
- Alice M. Arnold,
- Kristin L. Ayers,
- Nir Barzilai,
- Elizabeth J. Becker,
- Marian Beekman,
- Hélène Blanché,
- Kaare Christensen,
- Lene Christiansen,
- Joanna C. Collerton,
- Sarah Cubaynes,
- Steven R. Cummings,
- Karen Davies,
- Birgit Debrabant,
- Jean-François Deleuze,
- Rachel Duncan,
- Jessica D. Faul,
- Claudio Franceschi,
- Pilar Galan,
- Vilmundur Gudnason,
- Tamara B. Harris,
- Martijn Huisman,
- Mikko A. Hurme,
- Carol Jagger,
- Iris Jansen,
- Marja Jylhä,
- Mika Kähönen,
- David Karasik,
- Sharon L. R. Kardia,
- Andrew Kingston,
- Thomas B. L. Kirkwood,
- Lenore J. Launer,
- Terho Lehtimäki,
- Wolfgang Lieb,
- Leo-Pekka Lyytikäinen,
- Carmen Martin-Ruiz,
- Junxia Min,
- Almut Nebel,
- Anne B. Newman,
- Chao Nie,
- Ellen A. Nohr,
- Eric S. Orwoll,
- Thomas T. Perls,
- Michael A. Province,
- Bruce M. Psaty,
- Olli T. Raitakari,
- Marcel J. T. Reinders,
- Jean-Marie Robine,
- Jerome I. Rotter,
- Paola Sebastiani,
- Jennifer Smith,
- Thorkild I. A. Sørensen,
- Kent D. Taylor,
- André G. Uitterlinden,
- Wiesje van der Flier,
- Sven J. van der Lee,
- Cornelia M. van Duijn,
- Diana van Heemst,
- James W. Vaupel,
- David Weir,
- Kenny Ye,
- Yi Zeng,
- Wanlin Zheng,
- Henne Holstege,
- Douglas P. Kiel,
- Kathryn L. Lunetta,
- P. Eline Slagboom,
- Joanne M. Murabito
Affiliations
- Joris Deelen
- Max Planck Institute for Biology of Ageing
- Daniel S. Evans
- California Pacific Medical Center Research Institute
- Dan E. Arking
- McKusick-Nathans Institute of Genetic Medicine, Department of Genetic Medicine, Johns Hopkins University School of Medicine
- Niccolò Tesi
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Marianne Nygaard
- The Danish Aging Research Center, Department of Public Health, University of Southern Denmark
- Xiaomin Liu
- BGI-Shenzhen
- Mary K. Wojczynski
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Mary L. Biggs
- Department of Biostatistics, University of Washington
- Ashley van der Spek
- Department of Epidemiology, Erasmus MC
- Gil Atzmon
- Department of Biology, Faculty of Natural Science, University of Haifa
- Erin B. Ware
- Institute for Social Research, Survey Research Center, University of Michigan
- Chloé Sarnowski
- Department of Biostatistics, Boston University School of Public Health
- Albert V. Smith
- School of Public Health, Department of Biostatistics, University of Michigan
- Ilkka Seppälä
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University
- Heather J. Cordell
- Institute of Genetic Medicine, Newcastle University
- Janina Dose
- Institute of Clinical Molecular Biology, Kiel University
- Najaf Amin
- Department of Epidemiology, Erasmus MC
- Alice M. Arnold
- Department of Biostatistics, University of Washington
- Kristin L. Ayers
- Sema4, a Mount Sinai venture
- Nir Barzilai
- Departments of Medicine and Genetics, Albert Einstein College of Medicine
- Elizabeth J. Becker
- Bioinformatics Program, Boston University
- Marian Beekman
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Hélène Blanché
- Fondation Jean Dausset—CEPH
- Kaare Christensen
- The Danish Aging Research Center, Department of Public Health, University of Southern Denmark
- Lene Christiansen
- The Danish Aging Research Center, Department of Public Health, University of Southern Denmark
- Joanna C. Collerton
- Institute of Health & Society, Newcastle University
- Sarah Cubaynes
- MMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University
- Steven R. Cummings
- California Pacific Medical Center Research Institute
- Karen Davies
- Institute of Neuroscience, Newcastle University
- Birgit Debrabant
- Department of Public Health, University of Southern Denmark
- Jean-François Deleuze
- Fondation Jean Dausset—CEPH
- Rachel Duncan
- Institute of Health & Society, Newcastle University
- Jessica D. Faul
- Institute for Social Research, Survey Research Center, University of Michigan
- Claudio Franceschi
- Department of Applied Mathematics and Centre of Bioinformatics, Lobachevsky State University of Nizhny Novgorod
- Pilar Galan
- EREN, UMR U1153 Inserm/U1125 Inra/Cnam/Paris 13, Université Paris 13, CRESS
- Vilmundur Gudnason
- Icelandic Heart Association
- Tamara B. Harris
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH
- Martijn Huisman
- Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC
- Mikko A. Hurme
- Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University
- Carol Jagger
- Institute of Health & Society, Newcastle University
- Iris Jansen
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Marja Jylhä
- Faculty of Social Sciences (Health Sciences) and Gerontology Research Center (GEREC), Tampere University
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University
- David Karasik
- Azrieli Faculty of Medicine, Bar Ilan University
- Sharon L. R. Kardia
- School of Public Health, Epidemiology, University of Michigan
- Andrew Kingston
- Institute of Health & Society, Newcastle University
- Thomas B. L. Kirkwood
- Newcastle University Institute for Ageing, Newcastle University
- Lenore J. Launer
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University
- Wolfgang Lieb
- Institute of Epidemiology and Biobank PopGen, Kiel University
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University
- Carmen Martin-Ruiz
- Institute of Neuroscience, Newcastle University
- Junxia Min
- Institute of Translational Medicine, School of Medicine, Zhejiang University
- Almut Nebel
- Institute of Clinical Molecular Biology, Kiel University
- Anne B. Newman
- Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh
- Chao Nie
- BGI-Shenzhen
- Ellen A. Nohr
- Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark
- Eric S. Orwoll
- Bone and Mineral Unit, Oregon Health Sciences University
- Thomas T. Perls
- Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine
- Michael A. Province
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Marcel J. T. Reinders
- Delft Bioinformatics Lab, Delft University of Technology
- Jean-Marie Robine
- MMDN, Univ. Montpellier, EPHE, Unité Inserm 1198, PSL Research University
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Paola Sebastiani
- Department of Biostatistics, Boston University School of Public Health
- Jennifer Smith
- Institute for Social Research, Survey Research Center, University of Michigan
- Thorkild I. A. Sørensen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Kent D. Taylor
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- André G. Uitterlinden
- Department of Epidemiology, Erasmus MC
- Wiesje van der Flier
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Sven J. van der Lee
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus MC
- Diana van Heemst
- Department of Gerontology and Geriatrics, Leiden University Medical Center
- James W. Vaupel
- Max Planck Institute for Demographic Research
- David Weir
- Institute for Social Research, Survey Research Center, University of Michigan
- Kenny Ye
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Yi Zeng
- Center for Healthy Aging and Development Studies, National School of Development and Raissun Institute for Advanced Studies, Peking University
- Wanlin Zheng
- California Pacific Medical Center Research Institute
- Henne Holstege
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Douglas P. Kiel
- Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife
- Kathryn L. Lunetta
- Department of Biostatistics, Boston University School of Public Health
- P. Eline Slagboom
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Joanne M. Murabito
- NHLBI’s and Boston University’s Framingham Heart Study
- DOI
- https://doi.org/10.1038/s41467-019-11558-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Genome-wide association studies have only revealed a handful of genetic loci for longevity. Here, in a case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival percentile, the authors report two additional loci located in the APOE locus and near GPR78.
