Nature Communications (May 2018)

CCDC102B confers risk of low vision and blindness in high myopia

  • Yoshikatsu Hosoda,
  • Munemitsu Yoshikawa,
  • Masahiro Miyake,
  • Yasuharu Tabara,
  • Noriaki Shimada,
  • Wanting Zhao,
  • Akio Oishi,
  • Hideo Nakanishi,
  • Masayuki Hata,
  • Tadamichi Akagi,
  • Sotaro Ooto,
  • Natsuko Nagaoka,
  • Yuxin Fang,
  • Nagahama Study group,
  • Kyoko Ohno-Matsui,
  • Ching-Yu Cheng,
  • Seang Mei Saw,
  • Ryo Yamada,
  • Fumihiko Matsuda,
  • Akitaka Tsujikawa,
  • Kenji Yamashiro

DOI
https://doi.org/10.1038/s41467-018-03649-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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Myopic maculopathy is a complication of myopia that often progresses to blindness. Here, in a genome-wide association study, Hosoda et al. find that rs11873439 intronic to CCDC102B is associated with myopic maculopathy, but not with myopia, thus representing a risk factor independent of myopia.