A Structural Comparison of Oral SARS-CoV‑2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (Mpro) of SARS-CoV‑2 and MERS-CoV

• Pu Chen,
• Tayla J. Van Oers,
• Elena Arutyunova,
• Conrad Fischer,
• Chaoxiang Wang,
• Tess Lamer,
• Marco J. van Belkum,
• Howard S. Young,
• John C. Vederas,
• M. Joanne Lemieux

Affiliations

Pu Chen

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

Tayla J. Van Oers

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Elena Arutyunova

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

Conrad Fischer

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Chaoxiang Wang

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Tess Lamer

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Marco J. van Belkum

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Howard S. Young

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

John C. Vederas

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

M. Joanne Lemieux

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada