Siberian Journal of Life Sciences and Agriculture (Nov 2023)
STUDY OF STRESS-PROTECTIVE AND ANXIOLYTIC ACTIONS OF SCUTELLARIA BAICALENSIS GEORGI EXTRACT UNDER "SOCIAL" STRESS
Abstract
Background. The search for natural adaptogens is promising due to the possibility of expanding the range of drugs that contribute to the adaptation of the body to adverse environmental factors. Purpose. To study the stress-protective and anxiolytic action of the extract of Scutellaria baicalensis Georgi under conditions of "social" stress. Materials and methods. We used an extract of Scutellaria baicalensis Georgi. The study of the stress-protective and anxiolytic effects of the extract was carried out on 84 male non-linear rats aged 7-9 months. The first stage of the experiment involved the study of pharmacological actions in the absence of stress, and at the second stage, under conditions of “social” stress, the expected effects were determined on animals, in the groups of which individuals of dominant and submissive types of behavior were identified. Determination of the content of corticosterone, adrenaline and noradrenaline (nmol/l) was carried out by enzyme immunoassay. Results. It was established that in the norm, the experimental groups that received the extract of Scutellaria baicalensis Georgi, medicinal products "Mebikar®" and "Phezam®" showed a significant decrease in the level of corticosterone compared with the control group. At the second stage of the study in groups when modeling "social" stress, it was found that there were significant differences between the concentration of stress hormones in animals of dominant and submissive types. Administration of Scutellaria baicalensis Georgi extract reduced hormone levels for both aggressors and victims relative to the stressed control group. We observed a decrease in the concentration of corticosterone by 1.5 and 1.5 (p<0.05) times, the level of adrenaline by 3.2 and 3.1 (p<0.05) times, the content of norepinephrine by 1.6 and 1.6 (p<0.05) times for individuals of dominant and submissive types, respectively. The presence of the leveling effect of the Scutellaria baicalensis Georgi extract proves its anxiolytic and stress-protective effect. Conclusion. Scutellaria baicalensis Georgi extract at a dose of 100 mg/kg/day, when exposed to "social" stress, has a stress-protective and anxiolytic effect, reducing the severity of stress-induced changes, limiting hyperactivation of the central stress-realizing systems, correcting the endogenous antioxidant system of the body.
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